Pitavastatin

Pitavastatin 9 (Figure 7) contains a trisubstituted quinoline core and again retains the unsaturated E-heptenoic acid side chain with the identical (3R,5S) chirality found in fluvastatin.68'69 It differs from other synthetic statins by incorporating a cyclo-propyl moiety in place of the more typical iso-propyl ring substituent. Pitavastatin is approximately fourfold more potent than pravastatin (Ki = 1.7 nM). While detailed structure-activity data used to identify pitavastatin

HO, co2m

NyN R

27a R,, R2 = CH3: M = Na 27b R2 = CH3: R, = H: M = Na

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