Potential CRF receptor antagonists for anxiety

As CRF appears to plays a major role in the regulation of stress responses and the subsequent anxiety a concerted effort has focused on the search for orally active, nonpeptide antagonists. Examples of the different compound classes with high affinity for the CRF1 receptor are shown in Figure 9.98 Interestingly, while these molecules are chemically distinct, they appear to fit a common pharmacophore indicating that the receptor has strict requirements to allow a high-affinity interaction.98

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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