Potential CRF receptor antagonists for anxiety

As CRF appears to plays a major role in the regulation of stress responses and the subsequent anxiety a concerted effort has focused on the search for orally active, nonpeptide antagonists. Examples of the different compound classes with high affinity for the CRF1 receptor are shown in Figure 9.98 Interestingly, while these molecules are chemically distinct, they appear to fit a common pharmacophore indicating that the receptor has strict requirements to allow a high-affinity interaction.98

How To Win Your War Against Anxiety Disorders

How To Win Your War Against Anxiety Disorders

Tips And Tricks For Relieving Anxiety... Fast Everyone feels anxious sometimes. Whether work is getting to us or we're simply having hard time managing all that we have to do, we can feel overwhelmed and worried that we might not be able to manage it all. When these feelings hit, we don't have to suffer. By taking some simple steps, you can begin to create a calmer attitude, one that not only helps you feel better, but one that allows you the chance to make better decisions about what you need to do next.

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