Prolyl endopeptidase inhibitors

Prolyl endopeptidases hydrolyze proline-containing peptide hormones, several of which are implicated in learning and memory. 0N0-1603 (31) is a potent prolyl endopeptidase inhibitor (Ki = 12 nM) that reverses scopolamine-induced deficits in learning and memory in rats, restores decreased levels of choline and 5HT in aged rats and improves cognitive performance, and is also neuroprotective to CNS neurons undergoing apoptosis.44 While 0N0-1603 was advanced to phase II trials for senile dementia in Japan, it was discontinued in 1995.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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