Selective 5HT6 agonists and antagonists (e.g., WAY466 (68), Ro-63-0563 (69), SB-171046, and GW 742457) may show therapeutic promise while a selective 5HT7 receptor antagonist (SB-656104-A (70)) has recently been reported to modulate REM sleep, part of the sleep architecture that has long been associated with depression.
Agomelatine (71) is the first melatonergic (MT1 and MT2 receptor) agonist antidepressant, with several advantages over existing antidepressant treatments.56 Besides being an effective antidepressant, agomelatine improves the often disrupted sleep patterns of depressed patients, without affecting daytime vigilance. It has no effects on sexual function, tolerability problems, or discontinuation symptoms.61
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