Secretase inhibitors

Secretases are enzymes that process APP into nonamyloidogenic and amyloidogenic fragments and exist in three subtypes: a, b, and g. Cleavage of APP by a-secretase followed by g-secretase produces peptide fragments in the nonamyloidogenic pathway, whereas cleavage by b-secretase followed by g-secretase produces the Ab peptide fragments that aggregate and deposit as plaques (Figure 3). Thus, both b- and g-secretases are potential targets for AD therapy, although g-secretases have shown toxic liabilities. Two zinc-dependent metalloproteinases, ADAM10 and ADAM 17 (TACE), are candidate genes for a-secretase. Since the latter enzyme produces cleavage products with neurotrophic properties, inhibition of this enzyme may be counterproductive.

Domains: Extracellular Transmembrane Intracellular

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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