Side effectscontraindications

Metformin is generally well tolerated and safe. Gastrointestinal side effects (diarrhea, flatulence, abdominal discomfort, anorexia, nausea, and metallic taste) predominate and are commonly dose-related. Dose reduction, administration with food, or an extended-release formulation can improve drug tolerance. Over 50% of individuals tolerate the maximum daily dose of metformin, but 5-10% of people need to discontinue the drug altogether.65

Lactic acidosis is a rare, but potentially fatal, adverse complication, with an estimated incidence of 0.03 cases per 1000 patient-years. Most cases of lactic acidosis occur in a setting in which metformin therapy is continued inappropriately: during an acute or chronic medical condition that may alter the pharmacokinetics or renal clearance of metformin (renal impairment (plasma creatinine >1.5mgdL_ 1 in men; >1.4mgdL_ 1 in women)); or, in circumstances when hypoxia or reduced peripheral perfusion may occur (liver disease, cardiac or respiratory conditions, or a history of previous lactic acidosis).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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