Side effectscontraindications

The most common side effects associated with thiazolidinedione use are fluid retention, weight gain, and anemia. The weight increase may be attributed to an expansion of the subcutaneous fat depot and the development of peripheral edema. Plasma volume increases 6-7% on glitazone therapy and results in clinically notable edema in 4-6% of individuals, increasing the risk of symptomatic heart failure in predisposed individuals. The anemia associated with thiazolidinedione use is mild. Hepatotoxicity, as seen with the first thiazolidinedione (troglitazone), does not appear to be a drug-class effect. In clinical trials with rosiglitazone and pioglitazone, the incidence of hepatotoxicity and liver enzyme elevations is similar to placebo.

Losing Weight Without Starving

Losing Weight Without Starving

Tired of Trying To Loose Weight And It Never Works or You Have To Starve Yourself Well Here's A Weight Loss Plan That takes Care of Your Weight Problem And You Can Still Eat. In This Book, You’ll Learn How To Lose Weight And Not Feel Hungry! In An Easy Step-By-Step Process That Enables You To Feel Good About Loosing Weight As Well As Feeling Good Because Your Stomach Is Still Full.

Get My Free Ebook

Post a comment