Side effectscontraindications

The most common side effects associated with thiazolidinedione use are fluid retention, weight gain, and anemia. The weight increase may be attributed to an expansion of the subcutaneous fat depot and the development of peripheral edema. Plasma volume increases 6-7% on glitazone therapy and results in clinically notable edema in 4-6% of individuals, increasing the risk of symptomatic heart failure in predisposed individuals. The anemia associated with thiazolidinedione use is mild. Hepatotoxicity, as seen with the first thiazolidinedione (troglitazone), does not appear to be a drug-class effect. In clinical trials with rosiglitazone and pioglitazone, the incidence of hepatotoxicity and liver enzyme elevations is similar to placebo.

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