Subdural Hematoma Model

The rat lacks an arachnoid membrane, and thus the rat version of the SAH model involving injection of blood through the dura mater can also be thought of, and employed, as a subdural hematoma model. When the autologous, nonheparinized blood is injected through the dorsal burr hole through the dura mater, it will typically form a clot over the dorsal surface of the brain, mimicking a posttraumatic subdural hematoma. Just as is done in the management of human subdural hematomas, the experimental protocol involves surgical removal of the clot at a specified time followed by histological measurement of ischemic damage caused by the hematoma.11

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