As noted, BZs have been the primary treatment for anxiety for nearly half a century. Despite their proven efficacy and rapid onset of action, their use is limited by side effects, e.g., sedation and amnesia, the development of tolerance, and concerns about dependence and withdrawal.82'102 These side effects are a natural extension of their mechanism of action. Considerable effort has been expended over the past three decades to discover and develop novel, anxioselective BZ ligands that have improved side effect profiles.
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