The atheroprotective effects of highdensity lipoprotein cholesterol

While excessive mmLDL plays an important proinflammatory role in atherosclerosis, HDL and its associated apoA-I exert a corresponding cardiovascular benefit through the RCT pathway and several other important protective mechanisms.16 HDL also has beneficial antioxidant and anti-inflammatory properties and improves endothelial dysfunction. HDL contains two antioxidant enzymes, paraoxonase and platelet-activating factor (PAF) acetylhydrolase (PAFAH), that not only inhibit the oxidation of LDL but also help degrade oxidized phospholipids within oxLDL. HDL and its associated apoA-I protect endothelial cells from damage induced by oxLDL. HDL also displays anti-inflammatory properties, since pretreatment of human endothelial cells with HDL inhibits the cytokine-induced expression of cell adhesion molecules.

Alternatively, overall HDL functionality may be more important than absolute HDLc levels, since recent data indicate that HDL has both proinflammatory and anti-inflammatory properties. HDL isolated and characterized from the plasma of a small group of CHD patients exhibited a more proinflammatory profile in vitro based on its lipid peroxide content and ability to alter LDL-induced monocyte chemotaxis than HDL obtained from age- and sex-matched controls.23 These preliminary results suggest that the proinflammatory characteristics of HDL from CHD patients may be a better predictor of overall risk than absolute HDLc levels. However, no large trials have yet been conducted to confirm this hypothesis.

Back Pain Revealed

Back Pain Revealed

Tired Having Back Pains All The Time, But You Choose To Ignore It? Every year millions of people see their lives and favorite activities limited by back pain. They forego activities they once loved because of it and in some cases may not even be able to perform their job as well as they once could due to back pain.

Get My Free Ebook


Post a comment