The inflammatory cascade hypothesis

Reactive gliosis and microglial activation are consistent findings in AD brain with a host of inflammatory mediators (e.g., complement proteins, cytokines, and chemokines) being present at higher levels than in normal brain. These observations support an inflammatory hypothesis of AD that postulates that either neurodegeneration in AD brain is secondary to an inflammatory response to senile plaques and NFTs (cause) or inflammation triggers formation of NFTs and senile plaques, which in turn activate immune reactions that drive a cycle of neuronal destruction.20

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment