Thyrotropinreleasing hormone agonists

The neuropeptide, thyrotropin-releasing hormone (TRH), modulates CNS function, including activation of the cholinergic system. TRH analogs that overcome the short plasma half-life (4-5 min) include DN-1417 24, orotirelin 25, montirelin, RX-77368 26, MK-771 27, azetirelin, and posatirelin 28.41 Taltirelin (TA-0910: 29) is a small-molecule TRH agonist, with improved potency (up to 300-fold, depending on the biological assay) and pharmacokinetics (plasma t1/2 b 3 h) introduced in Japan in 2000 for the treatment of spinocerebellar degeneration. In animals, it dose-dependently increased extracellular ACh, potentiated ACh-induced neuronal excitation in cortical neurons, and inhibited ACh-induced desensitization. Taltirelin improved MMSE scores in demented patients and is reportedly in trials for AD.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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