Thyrotropin Releasing Hormone Analogs

It has long been known that tripeptide thyrotropin-releasing hormone (TRH) and certain of its analogs (Figure 12) have neuroprotective properties in a variety of CNS injury models. However, their use has been hindered by the fact that TRH and many of related compounds have analeptic, autonomic, and endocrine effects that preclude their full exploration. More recently a series of diiodoimidazole analogs (e.g., 2,4-diiodo-TRH and Compound 53a) and a series of cyclized dipeptides (diketopiperazines; Compound 57a), both of which are selective for neuroprotective effects and have less potential for the unwanted properties of the TRH, have been identified.85

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