Treatment of Hypertension

The current JNC VII guidelines recommend that antihypertensive therapy should start with a thiazide diuretic or a b-adrenoceptor antagonist as the first choice and newer drugs should only be added in special circumstances.1 Some investigators disagree, however, with the JNC recommendations and feel that drugs inhibiting RAS - ACE inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) - should be the first-line drugs in the treatment of hypertension, since they provide benefits beyond blood pressure reduction. Extended-release formulations of calcium antagonists are also often used as first-line therapy.

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