Unmet Medical Need

Renal disease may lead to dysfunction of the vascular endothelium that results in enhanced formation of vasoconstrictor peptides such as ET-1 and thromboxane, decreased formation of vasodilators such as EETs, NO, and prostacyclin, and increased formation of superoxide and inflammatory cytokines. These endothelial abnormalities impair pressure natriuresis and increase blood pressure. Although current antihypertensive drugs effectively reduce blood pressure by promoting the excretion of sodium and water and shift the pressure-natriuresis relationship back to normal, these drugs fail to correct all the pathophysiological changes that occur as a result of hypertension and endothelial dysfunction such a structural changes in renal vasculature, impaired renal autoregulation, tubular atrophy, interstitial fibrosis, and renal hypertrophy. Thus, future studies should focus on new drugs that can be used with current antihypertensive drugs to reduce blood pressure and correct the pathophysiological changes associated with renal dysfunction.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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