Unmet Medical Needs

The major unmet medical need for AD, as with all neurodegenerative diseases, is for disease-modifying therapies that can be used with reliable early diagnostic markers. There are currently no approved drugs that modify overall disease progression, although recent data suggest that donepezil may provide some protective benefit.33 Neuropsychiatric symptoms, including depression, pychosis, agitation (aggressive or disruptive behavior), and wandering associated with AD, are currently addressed with drugs used offlabel for AD (e.g., citalopram, clomipramine, sertraline, risperidone, olanzapine).

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