Unmet Medical Needs

The greatest unmet need in migraine is a broader recognition of the biological basis of the problem. It remains true after the decade of the triptans, 1995-2005, that the majority of migraine sufferers in the western world, and certainly the developing world, still do not access best-practice care. If diagnostic rates in most of the world reflect those of the US, where nearly 50% of migraine sufferers do not have the diagnosis made,65 and only a minority are treated with migraine-specific treatments, the opportunity to do good is huge. Any medicine development needs to bear this in mind. Having said that, the obvious need in acute treatment is a purely neuronally acting treatment that has no vascular side effects; this would be a major opportunity given the perceived cardiac safety issues with triptans.66 A drug with less recurrence, i.e., a greater 24-h sustained painfree response, would also be most welcome by the fully one-third of migraineurs who suffer headache recurrence: the attack is settled by treatment but reappears some hours later. For preventive medicines, a well-tolerated treatment would be a major, immediate, and welcome bonus, even if it did not help all sufferers, since the choice of side effects is daunting to patients. Lastly, the holy grail might be a medicine that would work as an acute therapy, preemptively if the patient feels an attack, and in short-term prophylaxis, for example when there will be a known trigger or an important event over some days. There is considerable opportunity.

Naturally Cure Your Headaches

Naturally Cure Your Headaches

Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?

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