Unmet Medical Needs

Due to the relatively poor efficacy to tolerability ratio for opioid analgesics in treating neuropathic pain, this area represents a major unmet medical need. While gabapentin and other adjuvant analgesics have been reported to be clinically effective in treating neuropathic pain, the efficacy rates are relatively small and are often accompanied by side effects of sufficient magnitude to limit compliance.7 This situation is not surprising in that essentially all clinically used analgesic adjuvants were originally developed to treat other indications. Their clinical utility in treating pain has been based largely on clinical serendipity.

In the case of inflammatory or nociceptive pain, opioids provide significant analgesic efficacy; however, long-term use of these analgesics is limited by both opioid-mediated side effects including constipation, and regulatory concern of opioid dependence and abuse liability. NSAIDs also provide moderate pain relief in these pain states, but are associated with GI disturbances. The COX-2 inhibitors represent an analgesic advance due to their enhanced GI safety profile; however, the long-term cardiovascular safety of these agents is controversial.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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