Vesicular neurotransmitter transporters VMATs and neurotransmitter transporters SCDNTs

Neurotransmitters are synthesized in neurons and concentrated in vesicles for their subsequent Ca2 + -dependent release into the synaptic cleft, where they are inactivated by either enzymatic degradation or active transport in neuronal and or glial cells by neurotransmitter transporters.17 Molecular cloning has allowed the pharmacological and structural characterization of a large family of related genes encoding Na+/Cl_-dependent neurotransmitter transporters (SCDNTs). The identification of a superfamily of monoamine transporters (dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT)) has been the focus of recent research on the association of monoamine transporters with psychiatric illnesses, as discussed below.18

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