Warfarin Heparin and Low MolecularWeight Heparins

Warfarin (Figure 4) inhibits vitamin K, which is essential for effective production of clotting factors II, VII, IX, X, and anticoagulant proteins C and S. Heparin inhibits thrombin (factor IIa), and factors Xa and IXa. Heparin is used to treat unstable angina and to prevent and treat venous thromboembolism. Low-molecular-weight heparins (LMWHs) are fragments of the heparin molecule that inhibit clotting factor Xa more than factor IIa. Dalteparin, enoxaparin, and tinzaparin are three such LMWHs.

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