Review Revicell White

Rosenberg, S. A. Cancer Principles and Practice of Oncology Lippincott-Raven Philadelphia, PA, 1997. 2. American Cancer Society. Cancer Facts and Figures. www.cancer.org (accessed Aug 2006). 3. Hanahan, D. Weinberg, R. A. Cell 2000, 100, 57-70. 4. Vogelstein, B. Kinzler, K. W Nat. Med. 2004, 10, 789-799. 5. Fearon, E. R. Vogelstein, B. Cell 1990, 61, 759-767. 6. Vogelstein, B. Fearon, E. R. Hamilton, S. R. Kern, S. E. Preisinger, A. C. Leppert, M. et al. N. Engl. J....

Signal Transduction and Cancer

What Neoplasia Tree Model Flow Chart

Cancer is a complex family of diseases characterized by host of cells that have acquired a malignant phenotype, rendering them more genetically unstable and less responsive to external stimuli and their own environment. In a landmark paper, Hanahan and Weinberg have described six 'hallmarks of cancer' that collectively lead to malignant growth5 self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis,...

References

National Breast Cancer Foundation Inc. and symptoms index.html accessed April 2006 . 2. Beatson, G. Lancet 1896, 2, 104-107. 3. Holtkamp, D. E. Greslin, S. C. Root, C. A. Lerner, L. J. Proc. Soc. Exp. Biol. Med. 1960, 105, 197-201. 4. Huppert, L. C. Fertil. Steril. 1979, 31, 1. 5. Beall, P T. Misra, L. K. Yound, R. L. Spjut, H. J. Evans, H. J. Leblanc, A. Calcif. Tissue Int. 1984, 36, 123-127. 6. Chakraborty, P K. Brown, J. L. Ruff, C. B. Nelson, M. F Mitchell, A. S. J. SteroidBiochem. Mol....

Conclusions

Much progress has been made in the last decade in the development and clinical use of antimetabolites as chemotherapeutics for the treatment of solid tumors. Both mono- and combination therapies have been found to be efficacious, and clinical trials are under way to determine efficacies against a greater variety of tumor types, and of regimens involving two-, three-, and four-drug combinations. Toxicities associated with the therapies have spurred investigation into methods of diagnosing tumors...

Erx

The clinical effectiveness of the taxanes has paved the way for the more recently discovered nontaxane microtubule-stabilizing agents. These new compounds, most discovered in the last 10 years, have provided new avenues for research in cancer chemotherapy, as well as significant challenges to the synthetic community to supply sufficient quantities of these frequently complex structures. The early clinical success of the epothilones is an encouraging first step toward the introduction of a...