Review Revicell White

Rosenberg, S. A. Cancer Principles and Practice of Oncology Lippincott-Raven Philadelphia, PA, 1997. 2. American Cancer Society. Cancer Facts and Figures. www.cancer.org (accessed Aug 2006). 3. Hanahan, D. Weinberg, R. A. Cell 2000, 100, 57-70. 4. Vogelstein, B. Kinzler, K. W Nat. Med. 2004, 10, 789-799. 5. Fearon, E. R. Vogelstein, B. Cell 1990, 61, 759-767. 6. Vogelstein, B. Fearon, E. R. Hamilton, S. R. Kern, S. E. Preisinger, A. C. Leppert, M. et al. N. Engl. J....

Signal Transduction and Cancer

What Neoplasia Tree Model Flow Chart

Cancer is a complex family of diseases characterized by host of cells that have acquired a malignant phenotype, rendering them more genetically unstable and less responsive to external stimuli and their own environment. In a landmark paper, Hanahan and Weinberg have described six 'hallmarks of cancer' that collectively lead to malignant growth5 self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis,...

References

National Breast Cancer Foundation Inc. and symptoms index.html accessed April 2006 . 2. Beatson, G. Lancet 1896, 2, 104-107. 3. Holtkamp, D. E. Greslin, S. C. Root, C. A. Lerner, L. J. Proc. Soc. Exp. Biol. Med. 1960, 105, 197-201. 4. Huppert, L. C. Fertil. Steril. 1979, 31, 1. 5. Beall, P T. Misra, L. K. Yound, R. L. Spjut, H. J. Evans, H. J. Leblanc, A. Calcif. Tissue Int. 1984, 36, 123-127. 6. Chakraborty, P K. Brown, J. L. Ruff, C. B. Nelson, M. F Mitchell, A. S. J. SteroidBiochem. Mol....

Conclusions

Much progress has been made in the last decade in the development and clinical use of antimetabolites as chemotherapeutics for the treatment of solid tumors. Both mono- and combination therapies have been found to be efficacious, and clinical trials are under way to determine efficacies against a greater variety of tumor types, and of regimens involving two-, three-, and four-drug combinations. Toxicities associated with the therapies have spurred investigation into methods of diagnosing tumors...

Ns Ch3

Like MTX, RTX utilizes the RFC and is an excellent substrate for FPGS, and much of its activity arises from its polyglutamates. Unlike MTX however, RTX is a relatively weak inhibitor of DHFR, instead exerting its efficacy through inhibition of TS. Because the polyglutamates are retained within cells for prolonged periods, RTX has a convenient dosing regimen of once every 3 weeks. As with other drugs dependent on the RFC and or FPGS, mutations or reduced expression of these proteins leads to...

Bn80927

BN-80927 29 is a homocamptothecin and a potent topo I poison, but also a catalytic inhibitor of topo II.154,155 It has excellent cytotoxicity against a number of human tumor cell lines in culture e.g., IC50 of 6.6 and 3 nM in HT29 colon and DU-145 prostate cell lines respectively .156 BN-80927 was more potent than SN38 6 in both wild-type and camptothecin-resistant tumor cell lines, and was highly effective in tumor xenografts of the human androgen-independent prostate tumors PC-3 and DU-145...

Erx

The clinical effectiveness of the taxanes has paved the way for the more recently discovered nontaxane microtubule-stabilizing agents. These new compounds, most discovered in the last 10 years, have provided new avenues for research in cancer chemotherapy, as well as significant challenges to the synthetic community to supply sufficient quantities of these frequently complex structures. The early clinical success of the epothilones is an encouraging first step toward the introduction of a...