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ICI182780 Arzoxifene

Figure 1 Structures of 17p-estradiol and various selective estrogen receptor modulators.

uterus, clomiphene and each of its components have been shown to stimulate the epithelium potently, and to stimulate a variety of estrogenic effects in OVX animals.9-11

The widespread clinical use of tamoxifen for the treatment of breast cancer has resulted in a large body of evidence with respect to its effects in other tissues. In several clinical trials, tamoxifen has demonstrated effectiveness in the preservation of bone mineral density at the lumbar spine, femoral neck, and forearm in postmenopausal women.12-15 These effects on bone density are accompanied by an estrogen-like reduction of serum markers of bone turnover.16 Likewise, significant decreases in risk factors for cardiovascular disease have been observed in postmenopausal women treated with tamoxifen.17 In general, significant decreases in low-density lipoprotein cholesterol and lipoprotein

From PMS To PPD

From PMS To PPD

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