Integrins and Angiogenesis

As described below, neovascularisation is an essential event in the growth of tumors. Tumor angiogenesis occurs as a result of the interaction between positive and negative regulators, and integrins have been shown to play an intimate role in these processes. In endothelial cells, several integrins are upregulated and associate with FAK in response to proangiogenic factors, such as VEGFand bFGF. Knockout studies have implicated a role for a5p1 and av integrins in angiogenesis, and ECM-derived fragments with potent antiangiogenic effects, such as endostatin and tumstatin, have been shown to act by blocking the action of integrins a5p1 and avb3, respectively.180

0 0

Post a comment