Introduction

The prolific use of chemical weapons during World War I and II, principally sulfur mustard (1, Figure 1), highlighted the powerful vesicant properties of this class of compounds, particularly toward the skin, eyes, and respiratory tract. A subsequent autopsy of soldiers revealed that exposure to 1 was characterized by the following: leukopenia, ulceration of the gastrointestinal tract, bone marrow aplasia, and dissolution of lymphoid tissue.1 The profound cytotoxic effect of 1 indicated that 1 or related compounds might be potentially efficacious chemotherapeutics. Unfortunately, the

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