Nucleoside Mimics

The nucleoside mimics tend to have a structural modification of the sugar residue, such as di-fluorination of the 2'-position (e.g., gemcitabine, 11) or inversion of hydroxyl configuration at 2'-position (cytarabine, 9). Others possess modified base residues, such as azacitidine (13) and decitabine (14). Some structures combine modification of the sugar with modification of the base, such as clofarabine (12) and nelarabine (15). The nucleoside mimics inhibit a variety of enzymes that are important in nucleoside synthesis or DNA replication, including thymidylate synthase, adenosine deaminase, ribonucleotide reductase, and DNA polymerase.

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