Spongistatin 5 (17): R1=Cl, R2=H Spongistatin 7 (18): R1=H, R2=H Spongistatin 8 (19): R1=H, R2=Ac Spongistatin 9 (20): R1=Cl, R2=Ac

Figure 6 Structures of spongistatins.

Eisai has subsequently developed substantially simplified analogs, ER-086526 10 and ER-076349 11, that demonstrate subnanomolar IC50 values versus a variety of human cancer cell lines. ER-086526 (E7389) is currently undergoing phase I human clinical trials.

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