Table 3 Related toxicities of therapeutic agents

Therapeutic agent (generic names)

Dactinomycin, mitoxantrone, bleomycin, mitomycin C, daunorubicin, doxorubicin, epirubicin, idarubicin

Cisplatin, carboplatin, oxaliplatin

Busulfan, chlorambucil, carmustine, lomustine, mechlorethamine, cyclophosphamide, thiotepa, ifosfamide, streptozocin melphalan, L-PAM

Procarbazine, temozolomide


Estramustine, vinorelbine, Vinblastine, vincristine

Docetaxel, paclitaxel

Etoposide, teniposide

Irinotecan, topotecan

Aldesleukin, interferon-a

Tamoxifen Megestrol acetate


Gefitinib, erlotinib

Bevacizumab Cetuximab

Mode of action/drug classification Antitumor antibiotics

Intercalating agents

Alkylating agents

Nonclassic alkylating agents

Biochemical modulating agent Antimicrotubule agents

Taxanes, antimitotic agents

Topoisomerase II inhibitors

Topoisomerase I inhibitors

Biologic response modifiers

Antiestrogen Hormonal agent

Estrogen receptor-modulating agent Antiangiogenic, immunomodulatory


EGFR/tyrosine kinase inhibitor Antiangiogenic

Monoclonal antibody to VEGF Antiangiogenic

Some related toxicities

Myelosuppression, cardiotoxicity, nausea/ vomiting/diarrhea, hepatic, renal, pulmonary, mucositis

Nephrotoxicity, myelosuppression, neurotoxicity, neuropathy, nausea/ vomiting, anaphylactic reaction

Myelosuppression, hypersensitivity, neurotoxicity, nausea/vomiting, skin, renal, hepatotoxicity, pulmonary skin, renal, hepatotoxicity, pulmonary

Myelosuppression, nausea/vomiting, flulike symptoms, infection, headache/ fatigue

Myelosuppression, nausea/vomiting, immunosuppression, gastrointestinal, hepatotoxicity, pulmonary, skin, renal, cardiovascular

Leukopenia, gastrointestinal, skin, nausea/ vomiting

Cardiovascular, respiratory, thrombosis, nausea/vomiting, gastrointestinal, neurologic, myelosuppression

Myelosuppression, hypersensitivity, respiratory, fluid retention, skin, neurotoxicity, diarrhea, cardiotoxicity

Myelosuppression, nausea/vomiting, gastrointestinal, hypersensitivity, alopecia, mucositis, hypotension

Gastrointestinal, myelosuppression, diarrhea, central nervous system, transient hepatotoxicity, skin, respiratory

Flu-like symptoms (fever, chills, malaise), vascular leak syndrome, myelosuppression, hepatoxicity

Menopausal symptoms, fluid retention, tumor flare-associated toxicities

Weight gain, thromboembolic events, nausea/vomiting, affects menses, heart failure

Teratogenic, neurologic, neutropenia, skin, sedation/fatigue, thromboembolic, constipation immunomodulatory

Pulmonary, potential embryotoxicity, diarrhea, skin, mild hepatotoxicity, asthenia/anorexia, nausea/vomiting

Gastrointestinal, hemorrhage, wound healing, hypertension, proteinuria

Cytarabine, floxuridine, fludarabine, Antimetabolites thioguanine, gemcitabine, methotrexate, pemetrexed, mercaptopurine, 5-fluorouracil, cladribine, capecitabine, hydroxyurea, trimetrexate

Table 3 Continued

Therapeutic agent (generic names)

Mode of action/drug classification

Some related toxicities

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