Tumor Angiogenesis

Cells cannot survive in the absence of oxygen and nutrients. As tumors grow beyond a certain size simple diffusion is no longer sufficient, necessitating the complementary development of a vascular network, a process described as neovascularization or angiogenesis. Control of physiological angiogenesis is highly complex, involving both positive and negative stimuli. Vascularization of tumors is associated with imbalance of these regulatory mechanisms, and increased vessel density and upregulation of proangiogenic factors correlates with more aggressive cancer and poorer prognosis (see 7.08 Kinase Inhibitors for Cancer).

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