Gastrin represents a family of peptides, secreted by antral G cells. Secretion is regulated by luminal, paracrine, endocrine and neural stimuli. The biologically active forms are 17 and 34 amino acid peptides. Gastrin 17 or 'little gastrin' (a heptadecapeptide) accounts for 90% of gastrin produced by the antral G cells. Gastrin 34 is also known as 'big gastrin'. The critical information for biological activity is contained in the carboxy-terminal tetrapeptide-amide.
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