The renal circulation is subject to autoregulation by the following mechanisms: A myogenic response, with arteriolar smooth muscle contraction in response to increased vessel wall tension;

ยป The intranephron tubuloglomerular feedback system, which describes the coup-

l ling of distal nephron flow with single nephron glomerular filtration rate.

y i l Humoral influences on the renal vasculature

y These are mediated by the following substances:

Vasoconstrictors: Angiotensin II Noradrenaline Thromboxane A2, B2 Leukotrienes D4, C4 Platelet-activating factor Endothelin-1 Vasopressin

Vasodilators: Prostaglandins E1, E2, I2 Acetylcholine Bradykinin Nitric oxide

Atrial natriuretic peptide (ANP)

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