The renal circulation is subject to autoregulation by the following mechanisms: A myogenic response, with arteriolar smooth muscle contraction in response to increased vessel wall tension;
» The intranephron tubuloglomerular feedback system, which describes the coup-
l ling of distal nephron flow with single nephron glomerular filtration rate.
y i l Humoral influences on the renal vasculature
y These are mediated by the following substances:
Vasoconstrictors: Angiotensin II Noradrenaline Thromboxane A2, B2 Leukotrienes D4, C4 Platelet-activating factor Endothelin-1 Vasopressin
Vasodilators: Prostaglandins E1, E2, I2 Acetylcholine Bradykinin Nitric oxide
Atrial natriuretic peptide (ANP)
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