Functional asplenia with normal-sized or enlarged spleen
Infiltration by leukaemia, lymphoma, multiple myeloma, mastocytosis
Early sickle cell disease
Benign and malignant vascular tumours Malabsorption syndromes
Reduced immune function
Post chemotherapy/radiation therapy
Antibody (IgM) and lymphokine production in lymphoid follicles (B cells). Macrophage activation; Production of opsonins: tuftsin, properdin. Reservoir:
Storage or normal sequestration of platelets, granulocytes; Recycling of iron;
The haematopoietic role is primarily seen during fetal life and in situations of bone marrow destruction or dysfunction.
Greer, J. P., Foerster, J., Lukens, J. N., Rodgers, G. M., Paraskeva, F. & Glader, B. Wintrobe's Clinical Haematology, 11th edn. vols. 1 and 2. Philadelphia: Lippincott, Williams & Wilkins, 2004.
Hoffbrand, A.V., Pettit, J.E. & Moss, P.A.H. Essential Haematology, 4th edn. Oxford:
Blackwell Science, 2001. Schiffmann, F.J. Haematologic Pathophysiology. Philadelphia: Lippincott-Raven Publishers, 1998.
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