g A conserved ligand-binding domain;

g A variable carboxy-terminal region.

"y These receptors belong to the steroid/thyroid hormone receptor superfamily.

§• The hormone-receptor complex translocates to the nucleus. Here it binds to y specific DNA sequences, termed hormone response elements. Alterations in the rate of transcription of the associated gene result. Steroid hormone receptors include numerous isoforms and structurally similar proteins (orphan receptors) of unknown function.

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