Mechanisms of diuretic action can be categorised primarily by site of action: Loop of Henle (thick ascending limb)

Inhibition of Na+/K+/2Cl- carrier Distal tubule and connecting segment

Inhibition of Na+/Cl- carrier Cortical collecting tubule Inhibition of Na channel

Classes of diuretics £

Proximal tubule £

Carbonic anhydrase inhibitors: block reabsorption of Na and HCO3 from prox- s imal tubule.

Osmotic diuretics: block water reabsorption in proximal tubule and descending loop of Henle.

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