Effects of angiotensin II

Vasoconstriction: systemic (preferentially coronary and cerebral) and intrarenal vascular smooth muscle constriction; Increased proximal tubular reabsorption of sodium;

Stimulation of aldosterone release: increased distal tubular reabsorption of sodium;

Arginine vasopressin (ADH) release: water retention; Stimulation of thirst;

Stimulation of sympathetic nervous system activity; Augmentation of adrenal medullary catecholamines; Direct inhibition of renin release in the kidney;

Renin

Substrate (Angiotensinogen)

Renin

Angiotensin I

Angiotensin II

Vasoconstriction

Increased aldosterone synthesis

Sodium Retention

Blood Pressure

Figure 6.3 Renin-angiotensin mechanism. ACE, angiotensin-converting enzyme.

Positive inotropic action on myocardium;

Increased endothelin secretion;

Stimulation of plasminogen activator inhibitor-!.

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