Vasoconstriction: systemic (preferentially coronary and cerebral) and intrarenal vascular smooth muscle constriction; Increased proximal tubular reabsorption of sodium;
Stimulation of aldosterone release: increased distal tubular reabsorption of sodium;
Arginine vasopressin (ADH) release: water retention; Stimulation of thirst;
Increased aldosterone synthesis
Figure 6.3 Renin-angiotensin mechanism. ACE, angiotensin-converting enzyme.
Positive inotropic action on myocardium;
Increased endothelin secretion;
Stimulation of plasminogen activator inhibitor-!.
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