Effects of stimulation of adrenergic receptors

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Alpha

Arteriolar and venular constriction; Iris dilatation; Intestinal relaxation;

Intestinal sphincter contraction; Pilomotor contraction; Bladder sphincter contraction; Contraction of the pregnant uterus; Ejaculation of seminal fluid. Beta: The beta receptor is a G-protein-coupled seven transmembrane span polypeptide.

Beta receptor numbers in tissues may decrease with chronic stimulation leading to desensitisation (down-regulation) or increase with chronic blockade (up-regulation). Beta 1

Cardioacceleration: chronotropic effect

Increased myocardial contractility: positive inotropic effect

Lipolysis

Secretion of renin by the juxtaglomerular apparatus

The cardiac positive inotropic effects result from increased calcium concentration due to phosphorylation of L-type calcium channels and phosphorylation of sarcolemmal calcium pumps. Beta 2 Vasodilatation Intestinal relaxation Uterine relaxation Bronchodilatation Calorigenesis Bladder wall relaxation

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