Plasma membrane receptors are integral membrane proteins with three basic domains:
An extracellular ligand-binding domain;
A transmembrane domain, usually with seven spans of the membrane, with an exposed N-terminal and a C-terminal projecting into the cytosol; An intracellular or cytoplasmic domain. Intracellular receptors generally consist of a single polypeptide chain with: A variable -NH2 terminus domain;
A conserved deoxynucleic acid (DNA)-binding domain (response element), which is a zinc finger motif;
Receptors for molecules used in signalling
Receptors for lipid-soluble signalling molecules
Steroid hormone family of receptors; Catalytic, cytosolic receptors.
Ligand-gated ion channel receptors; Catalytic, membrane receptors; Receptors coupled directly to a cytosolic enzyme; G-protein-coupled membrane receptors.
5 A variable hinge region;
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