Hypogonadism

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This is defined as inadequate gonadal function, manifested by defects in game-togenesis and/or secretion of gonadal hormones. The manifestations vary according to the sex of the subject, and whether the onset is pre- or post-pubertal. The features of pre-pubertal hypogonadism are those of pubertal delay, while the features of post-pubertal hypogonadism are often more subtle.

Mechanisms of hypogonadism

These can be categorised as: Primary or hypergonadotrophic hypogonadism due to ovarian or testicular failure, with lack of sex steroid production by the gonads; Secondary or hypogonadotrophic hypogonadism, due to either failure of the hypothalamic GnRH pulse generator, or to pituitary failure to secrete gonadotrophins;

End organ resistance to sex steroids.

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