Mechanisms of transport across the bloodbrain barrier

Electrolyte transport: simple diffusion through capillary endothelial cells; diffusion through pores within and between cells; and carrier mediated active and/or passive transport.

e Micronutrient transport (of vitamins, nucleotides, purine bases): facilitated dif-

3 fusion at the capillary endothelial cell; active transport at the choroid plexus p y epithelium.

I Carrier mediated transport systems in the CNS:

y Monosaccharides: D-glucose

Monocarboxylic acids: L-lactate Neutral amino acids: L-leucine Basic amino acids: L-arginine Dicarboxylic acids: L-glutamate Amines: choline Nucleosides: adenosine Purines

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