Metabolic effects

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Protein metabolism Increased amino acid uptake and synthesis of protein Increased protein degradation and turnover

Serum thyroxine e a

Comprises the following components: Free thyroxine: 0.03%;

Bound to thyroxine-binding globulin (TBG) (an alpha 1-alpha 2-glycoprotein) (70%); Bound to thyroxine-binding pre-albumin (TBPA) or thyretin (comprised of four identical polypeptide units) (20%); Bound to albumin (10%).

Carbohydrate metabolism Increased glucose uptake by adipose, liver and muscle cells Increased glycolysis

Increased gluconeogenesis and glycogenolysis in the liver Increased insulin secretion Fat metabolism Increased fat mobilisation and lipolysis Increased fat oxidation Increased oxygen consumption in all cells except brain, anterior pituitary, spleen and testes: calorigenic action, increasing the basal metabolic rate. This is achieved by stimulation of synthesis of the cell membrane Na+/K+-ATPase system. CNS maturation in utero and in early infancy.

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