S

l Increased capillary permeability.

y Atrial natriuretic peptide release is increased in any hypervolaemic state, e.g.

heart failure, renal failure. Atrial natriuretic peptide resistance does not interfere with the response to chronic volume expansion as induced by oral salt loading or by mineralocorticoid escape.

Measurement of plasma natriuretic peptides is being used clinically for the early diagnosis of heart failure and for the diagnosis of left ventricular dysfunction.

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