Synaptic vesicle proteins

Synaptophysin g Synaptotagmin y .

Syntaxin

Synaptobrevin/VAMP (vesicle-associated membrane protein) Rab3 and rabphilin

SV-2 : large glycoprotein with 12 transmembrane domains Vacuolar proton pump: membrane ATPase potential (epsp). A single epsp normally produces insufficient depolarisation to reach threshold for generation of an action potential. Generation of a post-synaptic impulse requires summation of several epsps. An epsp is associated with simultaneous increase in membrane permeability to potassium and sodium.

Stimulation of the presynaptic nerve fibre at an inhibitory synapse results in a hyperpolarisation of the postsynaptic membrane: an inhibitory postsynaptic potential (ipsp). The effect of ipsps is to move the membrane potential away from the threshold for excitation, thus opposing the effect of epsps.

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