Tests for fibrinolysis

* Direct measurement of the clot lysis time, by manual or viscoelastic tests. The changes in viscosity of blood as it clots can be measured using thrombo-elastography, or by the Sonoclot test, which measures the changing impedance on an ultrasonic probe that is immersed in a coagulating blood sample.

* Measurement of the end-products of fibrin degradation. Fibrin degradation products, resulting from the cleavage of fibrin monomers and polymers, using a latex agglutination assay. Cleavage of cross-linked fibrin by plasmin yields dimeric units comprising one D-domain from each of two adjacent fibrin units (D-dimers), which are measured either by enzyme-linked immunosorbent assays or latex agglutination techniques.

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