Vasoactive intestinal peptide

Vasoactive intestinal peptide is a 28 amino acid peptide, released from nerve terminals.

It acts on cells bearing VIP receptors, which are G-protein-coupled receptors. Vasoactive intestinal peptide acts as a neurotransmitter throughout the central and peripheral nervous systems. It is a major component of the non-adrenergic non-cholinergic nervous system in the gut. Stimulation of blood flow in the gastrointestinal tract is associated with epithelial secretion and absorption and smooth muscle relaxation.

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It also promotes the secretion of fluid and bicarbonate from cholangiocytes in the bile ducts.

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