B 14

12 Intestinal villus

B. Peristaltic reflex

Contracted

Stretch sensor (stimulated by previous passage of bolus)

Q Q Q Longitudinal muscles

Myenteric plexus

Contracted

Stretch sensor (stimulated by previous passage of bolus)

Q Q Q Longitudinal muscles

Myenteric plexus

Peristalsis Bolus Stretch Sensor

Movement

Disinhibition

Neuron

Sensory (+) Interneuron (+) Interneuron (-) Interneuron (+) Motor, type 2 (+) Motor (-)

Transmitter

Serotonin ?

ACh ACh VIP

Movement

Disinhibition

Contracted

Neuron

Sensory (+) Interneuron (+) Interneuron (-) Interneuron (+) Motor, type 2 (+) Motor (-)

Transmitter

Serotonin ?

ACh ACh VIP

Spike Or bursts

Spike Or bursts

0 6 12 18 24 BO B6 42 48 54 Time (s) (After Guyton)

D. Pacemaker rate

Maximal rate of the respective pacemaker situated towards the anus

Maximal rate of the respective pacemaker situated towards the anus

Intrinsic rate

Distance in small intestine tu CT

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