Vicious circle of the progression of nephropathy

Figure 2.7 If the kidney corpuscles are damaged through diabetes, a vicious circle develops ever fewer corpuscles have to do ever more work higher rates of protein deposition and higher blood pressure lead to the corpuscles being destroyed more rapidly. Damage caused by high blood pressure , More protein deposits in the corpuscles Damage to tfie corpuscles through diabetes Figure 2.7 If the kidney corpuscles are damaged through diabetes, a vicious circle develops ever fewer corpuscles have to...

With nephropathy is there a point of no return

Another important question is whether there is any benefit of good blood sugar control once the signs of kidney failure, either micro- or even macroalbuminuria, have appeared. This was disputed for a long time. The opinion was that there was a point of no return, after which there could be no reversing the course of the disease - it would progress inexorably until dialysis was necessary, regardless of how well controlled the blood sugar level was. But the studies of recent years have shown...

How does diabetes affect the kidneys

Generally, the changes produced in the kidneys by diabetes occur very slowly, taking place over years (Table 2.2, Figure 2.4). If they are recognized early, they can - with the right treatments - be reversed. The changes start, at the onset of diabetes, with an increase in the size of the kidneys and in the amount of blood passing through them. This first, early stage is known as 'the hypertrophy and hyperfunction stage' (stage 1) because of the enlarged kidneys, enriched in blood. Even at this...

How is kidney function measured

When the kidneys are no longer working efficiently, tell-tale signs appear in the blood and the urine - but not until a certain stage. In the Figure 2.3 Scanning electron microscopy shows the various large pores in the basal membrane, through which the blood is filtered. 3 Figure 2.3 Scanning electron microscopy shows the various large pores in the basal membrane, through which the blood is filtered. 3 blood, for example, creatine and urea accumulate. Creatine is a waste product of muscle...

How failing kidney function affects diabetes management

To achieve good blood sugar control in the presence of failing kidney function is a difficult task for patient and doctor. There are various reasons for this. In some people with diabetes the insulin sensitivity changes, for reasons that are often unclear the tissues no longer respond as well to insulin. This can lead to a worsening of the diabetes. Insulin - whether made by the body or injected as a drug - is partly broken down in the kidneys. When the kidneys are not functioning properly,...