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The Parkinson's-Reversing Breakthrough

What is Parkinsons Disease

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Diagnosis of six neurologists using these criteria when evaluating clinical vignettes (values reported are from the first clinical evaluation)

Features extracted from 83 cases with detailed clinical information

0.72 through 0.91

Diagnosis of four physicians reviewing the first clinical evaluation of patients with dementia and/or Parkinsonism k

Sens., sensitivity; Spec., specificity; PPV, positive predictive value; NPV, negative predictive value; k, kappa statistic (interrater reliability); NINDS-SPSP, National Institute of Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy, Inc.; PSP, progressive supranuclear palsy.

Three published studies have reported the diagnostic accuracy of the PSP. Two of the studies used overlapping cases but different methodology (Litvan et al., 1996; Litvan et al., 1997). Validity values are given in percentages.

(Adapted with permission from Litvan I, Bhatia KP, Burn DJ, et al. SIC task force appraisal of clinical diagnostic criteria for Parkinsonian disorders. Mov Dis 2003;18:467-486.)

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