Disturbed function of one or more peripheral nerve(s) resulting in weakness/paralysis or sensory dysfunction because of either conduction block in motor nerve fibers or axonal loss.
Conduction block is related to demyelination with preservation of axon continuity. Remyelination may be rapid and complete. If axonal interruption takes place, axonal degeneration occurs below the site of interruption and recovery is often slow and incomplete. Sensory symptoms and sensory loss may affect all modalities or be restricted to certain forms of sensation. Diagnostic criteria:
a. Clinical demonstration of motor/sensory disturbances in the distribution of a peripheral nerve and/or b. Abnormalities on nerve conduction studies or electromyogram (EMG) (i.e., concentric needle examination).
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