Acid Secretion

There are numerous mediators which affect the secretion of acid by the parietal cell. In basic terms, the parietal cell is responsive to five main mediators which influence acid secretion. Three of these agents stimulate acid production while the other two have an inhibitory effect on acid production. Gastrin, histamine, and acetylcholine (via vagal enervation) all have a stimulating effect on acid production. Conversely, somatostatin and prostaglandin have an inhibitory effect on acid production.

References

1. Greenfield LJ, Mulholland M, Oldham KT et al. Surgery scientific principals and practice. 2nd ed. Philadelphia: Lippincott-Raven, 1997.

2. Sabiston DC, Lyerly HK. Textbook of Surgery. 15th ed. Philadelphia: WB. Saunders Co., 1997.

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