The administration of antibiotics is generally not disputed, but the length of treatment is. For perforated appendicitis, some surgeons will use extended spectrum synthetic penicillins. Others will use ampicillin, gentamycin, and metronidazole. Nevertheless, monotherapy with a second generation cephalosporin is more economical and equally efficient, even in cases of perforated appendicitis with abscess formation. A total of 3 days of antibiotic therapy above and beyond the point where the patient is no longer febrile or has a leukocytosis is sufficient.

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