BE results from severe gastroesophageal reflux diseases (GERD). It usually presents in the sixth decade of life with a male-to-female ratio of 3:1.


They occur most commonly in the distal third of the esophagus.


Refluxed gastric acid, proteases and bile erode normal squamous epithelium with residual pluripotential basal cells differentiate along varying lines. A wide variety of genetic events and mechanisms appear to play a role in the progression of Barrett's to adenocarcinoma. .Development of Barrett's is associated with chromosomal loss (4q, 5q, 16q,18q). Growth factors and cell adhesion molecules also may play a role (EGFR, c-erbB2 and src). However, a uniform molecular pathway has not been described.

Barrett's Mucosa

• Gastric fundus-type epithelium

• Junctional-type epithelium

• Specialized columnar epithelium — highest association with carcinoma

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